{"title":"Prenylated isoflavonoids with anti-inflammatory activities from the twigs and leaves of Maclura fruticosa.","authors":"Xue-Mei Zhou, Hui-Qiong Li, Jing-Yi Yu, Ni Zuo, Xiao-Ting He, Jing-Jing Zhang, Ling Ding, Xiao-Li Li, Xing-Jie Zhang, Wei-Lie Xiao","doi":"10.1016/j.fitote.2025.106489","DOIUrl":null,"url":null,"abstract":"<p><p>Six new prenylated isoflavonoids, named maccosas A-F (1-6), together with ten known prenylated isoflavonoids (7-16) were isolated from the twigs and leaves of Maclura fruticosa. Compounds were isolated by various column chromatographic methods including silica gel, sephadex LH-20, and semi-preparative HPLC. Their structures were elucidated by a combination of 1D and 2D NMR techniques, mass spectrometry, and comparison of their spectral data with those in the literature. Furthermore, compounds 1 and 7 exhibited anti-inflammatory activity with IC<sub>50</sub> values of 4.11 and 1.45 μM. Detection of cellular pyroptosis and western blot assay suggested that compound 1 reduced the number of PI-positive cells and inhibited Nigericin-induced pyroptosis of J774A.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106489"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.fitote.2025.106489","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Six new prenylated isoflavonoids, named maccosas A-F (1-6), together with ten known prenylated isoflavonoids (7-16) were isolated from the twigs and leaves of Maclura fruticosa. Compounds were isolated by various column chromatographic methods including silica gel, sephadex LH-20, and semi-preparative HPLC. Their structures were elucidated by a combination of 1D and 2D NMR techniques, mass spectrometry, and comparison of their spectral data with those in the literature. Furthermore, compounds 1 and 7 exhibited anti-inflammatory activity with IC50 values of 4.11 and 1.45 μM. Detection of cellular pyroptosis and western blot assay suggested that compound 1 reduced the number of PI-positive cells and inhibited Nigericin-induced pyroptosis of J774A.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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