Recent Advances in Asymmetric Synthesis of Chiral-at-Sulfur Sulfoximines

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2025-03-19 DOI:10.1021/acscatal.5c01027

Muhammad Suleman, Tianming Huang, Tao Zhou, Zhiyuan Chen, Bingfeng Shi

引用次数: 0

Abstract

Sulfoximines with S-stereocenters have gained significant attention due to their diverse biological activities and growing applications in medicinal chemistry, agriculture, and materials science. Over the past two decades, substantial progress has been made in the development of synthetic methodologies for constructing S-stereogenic sulfoximines. Key strategies include transition-metal-catalyzed enantioselective C–H functionalization and asymmetric organocatalysis. Additionally, miscellaneous reactions involving addition/substitution processes with S-nucleophiles or S-electrophiles, such as sulfides, sulfoxides, sulfonimidates, sulfonimidoyl halides, and sulfenamides, offer alternative routes for synthesizing S-stereocenter sulfoximines. This Perspective aims to provide a comprehensive overview of the advancements made since 2010, emphasizing various synthetic approaches and their applications in the creation of S-stereogenic sulfoximines.

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.