Evaluation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer through Shear-Wave Elastography.

IF 1.1 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Qingfu Qian, Minling Zhuo, Yue Yu, Xiaodong Lin, Ensheng Xue, Zhikui Chen
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引用次数: 0

Abstract

Background: There remains a lack of methods to accurately assess the efficacy of neoadjuvant chemoradiotherapy for locally advanced rectal cancer.

Objective: This study aimed to investigate the value of shear-wave elastography in evaluating the treatment response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer.

Materials and methods: This prospective observational study enrolled 275 patients with locally advanced rectal cancer who received neoadjuvant chemoradiotherapy during September 2021-March 2023. All patients underwent endorectal ultrasound and shear-wave elastography examination before total mesorectal excision. Clinical baseline data, endorectal ultrasound, and shear-wave elastography examination data were collected from all patients. The independent predictors of complete response were analyzed and screened, followed by the establishment of a logistic regression model. The diagnostic efficacy of the model was compared with that of radiologists.

Results: The results of binary multivariate logistic regression suggested that the mean elastography value of the tumor lesion acted as an independent predictor for the diagnosis of complete response [OR: 0.894 (0.816, 0.981)]. The optimal cutoff value was 14.6 kPa. The area under the receiver operating characteristic curve of the model for predicting complete response in the training and test cohorts was 0.850 and 0.824, respectively. The diagnostic accuracy of the model was significantly higher than that of radiologists (P < 0.001).

Conclusion: Shear-wave elastography can be used as a feasible method to evaluate the complete response of locally advanced rectal cancer after neoadjuvant chemoradiotherapy.

剪切波弹性成像评价局部晚期直肠癌新辅助放化疗疗效。
背景:目前仍缺乏准确评估局部晚期直肠癌新辅助放化疗疗效的方法。目的:探讨剪切波弹性成像在评价局部晚期直肠癌新辅助放化疗疗效中的价值。材料和方法:本前瞻性观察性研究纳入了275例局部晚期直肠癌患者,于2021年9月至2023年3月期间接受了新辅助放化疗。所有患者在全肠系膜切除术前均行直肠内超声和剪切波弹性成像检查。收集所有患者的临床基线资料、直肠内超声和剪切波弹性成像检查资料。对完全缓解的独立预测因素进行分析筛选,建立logistic回归模型。将模型的诊断效果与放射科医师的诊断效果进行比较。结果:二元logistic回归结果显示,肿瘤病灶的平均弹性成像值可作为诊断完全缓解的独立预测因子[OR: 0.894(0.816, 0.981)]。最佳截止值为14.6 kPa。该模型用于预测训练组和测试组完全反应的受试者工作特征曲线下面积分别为0.850和0.824。模型的诊断准确率显著高于放射科医师(P < 0.001)。结论:剪切波弹性成像可作为评价局部晚期直肠癌新辅助放化疗后完全缓解的一种可行方法。
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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
246
审稿时长
1 months
期刊介绍: Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.
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