{"title":"The correlation between the ultrasound examination parameters and the pathological characteristics of papillary thyroid carcinomas.","authors":"Lei Yang, Yang Luo, Zhiyong Li","doi":"10.12669/pjms.41.3.10566","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the correlation between ultrasound (US) examination parameters and pathological characteristics of papillary thyroid carcinomas (PTC).</p><p><strong>Methods: </strong>A retrospective analysis was conducted using clinical data from 89 patients with PTC (malignant group) and 89 patients with benign thyroid nodules (benign group) who underwent US at Chengdu Shuangliu Hospital of Traditional Chinese Medicine between February 2021 to February 2023. The correlation between ultrasound parameters and pathological features of PTC was analyzed.</p><p><strong>Results: </strong>Ultrasound parameters in the malignant group were significantly different from those in the benign group (<i>P</i><0.05). Peak systolic blood flow velocity (PSV), pulsation index (PI), and resistance index (RI) were significantly higher in patients with malignant lymph node metastasis (LNM) and stage III-IV PTC. In contrast, peak intensity (Peak), mean transit time (MTT), time to peak (TTP), and area under curve (AUC) were significantly lower than those in patients without LNM and stage I-II (<i>P</i><0.05). Spearman's analysis revealed significant correlations between ultrasound parameters, LNM, disease staging, and gene mutations (<i>P<0.05</i>). Of the 89 PTC patients, 27 had disease recurrence, and five died during the follow-up. The poor prognosis group had significantly higher PSV, PI, and RI and lower Peak, MTT, TTP, and AUC compared to the good prognosis group (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Ultrasound is a valuable tool for diagnosing and evaluating papillary thyroid carcinoma (PTC). It shows strong correlations between ultrasound parameters and pathological features, including lymph node metastasis and disease staging, aiding early diagnosis and prognosis prediction.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 3","pages":"848-855"},"PeriodicalIF":1.2000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911734/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12669/pjms.41.3.10566","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To evaluate the correlation between ultrasound (US) examination parameters and pathological characteristics of papillary thyroid carcinomas (PTC).
Methods: A retrospective analysis was conducted using clinical data from 89 patients with PTC (malignant group) and 89 patients with benign thyroid nodules (benign group) who underwent US at Chengdu Shuangliu Hospital of Traditional Chinese Medicine between February 2021 to February 2023. The correlation between ultrasound parameters and pathological features of PTC was analyzed.
Results: Ultrasound parameters in the malignant group were significantly different from those in the benign group (P<0.05). Peak systolic blood flow velocity (PSV), pulsation index (PI), and resistance index (RI) were significantly higher in patients with malignant lymph node metastasis (LNM) and stage III-IV PTC. In contrast, peak intensity (Peak), mean transit time (MTT), time to peak (TTP), and area under curve (AUC) were significantly lower than those in patients without LNM and stage I-II (P<0.05). Spearman's analysis revealed significant correlations between ultrasound parameters, LNM, disease staging, and gene mutations (P<0.05). Of the 89 PTC patients, 27 had disease recurrence, and five died during the follow-up. The poor prognosis group had significantly higher PSV, PI, and RI and lower Peak, MTT, TTP, and AUC compared to the good prognosis group (P<0.05).
Conclusions: Ultrasound is a valuable tool for diagnosing and evaluating papillary thyroid carcinoma (PTC). It shows strong correlations between ultrasound parameters and pathological features, including lymph node metastasis and disease staging, aiding early diagnosis and prognosis prediction.
期刊介绍：
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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