Complications following endoscopic transsphenoidal surgery for pituitary adenoma—special focus on intrasellar pressure

IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-03-19 DOI:10.1007/s00701-025-06495-7

Gabriel Simander, Per Olof Eriksson, Sara Viirola, Peter Lindvall, Lars-Owe D. Koskinen

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引用次数: 0

Abstract

Purpose

The aim of this study was to explore risk factors for intraoperative events and postoperative complications of endoscopic transsphenoidal surgery (ETS) for pituitary tumors, and the role of intrasellar pressure (ISP) in relation to complications.

Methods

The study was a single-center, retrospective, consecutive, observational study, with ISP data collected prospectively. After exclusions, the study population encompassed 69 patients. All had ISP measured intraoperatively during ETS for a pituitary adenoma and underwent standardized postoperative observations and follow-up. Data on complications within 3 months after surgery and some risk factors were collected retrospectively.

Results

Decreased risk of postoperative cerebrospinal fluid leakage was seen with higher age. Large tumor volume was associated with higher risk of intraoperative events. ISP was not associated with complication frequency, but patients with ISP > 20 mmHg had increased frequency of postoperative epistaxis.

Conclusion

This study confirms earlier findings of low age as a possible risk factor for postoperative cerebrospinal fluid leakage. Tumor volume is suggested to be associated with higher complication risk. ISP does not seem to be a significant risk factor for intraoperative events or postoperative complications following ETS. Predictive risk factors for surgical complications after ETS are still not satisfactorily explained and heterogeneous definitions of complications are problematic in this context.

查看原文本刊更多论文

垂体腺瘤内窥镜经蝶窦手术后的并发症--特别关注蝶窦内压力

目的本研究旨在探讨垂体瘤内窥镜经蝶手术（ETS）术中事件和术后并发症的风险因素，以及鞘内压（ISP）在并发症中的作用。方法本研究是一项单中心、回顾性、连续性、观察性研究，ISP数据为前瞻性收集。经排除后，研究对象包括 69 名患者。所有患者都在垂体腺瘤 ETS 术中测量了 ISP，并接受了标准化的术后观察和随访。回顾性收集了术后 3 个月内的并发症数据和一些风险因素。肿瘤体积越大，术中发生并发症的风险越高。ISP与并发症发生频率无关，但ISP超过20 mmHg的患者术后鼻衄发生频率增加。肿瘤体积被认为与较高的并发症风险有关。ISP似乎不是ETS术中事件或术后并发症的重要风险因素。ETS术后并发症的预测风险因素仍未得到令人满意的解释，并发症的不同定义在这方面也存在问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.