Multiplex targeting of immune-modulating genes in cancer

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-03-19 DOI:10.1038/s41590-025-02115-9

Erica L. Braverman, Dario A. A. Vignali, Creg J. Workman

引用次数: 0

Abstract

A combinatorial therapeutic strategy that modulates several gene targets within the tumor microenvironment through a CRISPR–Cas13d system leads to a significant boost in anti-tumor immunity and ultimately tumor clearance.

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免疫调节基因在癌症中的多重靶向作用

通过CRISPR-Cas13d系统调节肿瘤微环境中的几个基因靶点的组合治疗策略可显著增强抗肿瘤免疫并最终清除肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.