The Role of HDAC3 in Pulmonary Diseases.

IF 4.6 2区 医学 Q1 RESPIRATORY SYSTEM
Lung Pub Date : 2025-03-17 DOI:10.1007/s00408-025-00798-3
Leyu Hong, Ming Ni, Fei Xue, Tao Jiang, Xuanpeng Wu, Chenxi Li, Shuhao Liang, Tianhao Chen, Chao Luo, Qifei Wu
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引用次数: 0

Abstract

Histone deacetylases (HDACs), a class of enzymes involved in epigenetic modifications, play a pivotal role in modulating chromatin structure and gene expression. Among these, histone deacetylase 3 (HDAC3) has emerged as a key regulator in diverse cellular pathophysiological processes. The remarkable therapeutic potential of HDAC inhibitors in lung cancer has intensified research into the role of HDAC3 in pulmonary diseases. Through deacetylating histones and non-histone proteins, HDAC3 has been increasingly recognized for its critical involvement in regulating inflammatory responses, fibrotic processes, and oncogenic signaling pathways, positioning it as a compelling therapeutic target. This review systematically examines the structural and functional features of HDAC3 and discusses its multifaceted contributions to pulmonary pathologies, including lung injury, pulmonary fibrosis, and lung cancer. Additionally, we critically evaluate advances in HDAC inhibitor-based therapies for lung cancer, with emphasis on the development of HDAC3-targeted therapies. As a promising therapeutic target for pulmonary diseases, HDAC3 needs to be further investigated to elucidate its regulatory mechanisms and facilitate the development of selective inhibitors for clinical translation.

HDAC3在肺部疾病中的作用
组蛋白去乙酰化酶(hdac)是一类参与表观遗传修饰的酶,在调节染色质结构和基因表达中起着关键作用。其中,组蛋白去乙酰化酶3 (HDAC3)已成为多种细胞病理生理过程的关键调节因子。HDAC抑制剂在肺癌中的显著治疗潜力已经加强了对HDAC3在肺部疾病中的作用的研究。通过去乙酰化组蛋白和非组蛋白,HDAC3因其在调节炎症反应、纤维化过程和致癌信号通路中的重要作用而越来越被人们所认识,并将其定位为一个引人注目的治疗靶点。本文系统地研究了HDAC3的结构和功能特征,并讨论了其在肺损伤、肺纤维化和肺癌等肺部病理中的多方面作用。此外,我们批判性地评估基于HDAC抑制剂的肺癌治疗的进展,重点是HDAC3靶向治疗的发展。作为肺部疾病的一个有前景的治疗靶点,HDAC3需要进一步研究以阐明其调控机制,并促进开发用于临床翻译的选择性抑制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lung
Lung 医学-呼吸系统
CiteScore
9.10
自引率
10.00%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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