Potential Risks of Minoxidil in Pheochromocytoma and Paraganglioma: A Commentary on Safety Concerns and Mechanisms.

IF 4.6 2区医学 Q1 NEUROSCIENCES

Molecular Neurobiology Pub Date : 2025-07-01 Epub Date: 2025-03-17 DOI:10.1007/s12035-025-04842-4

Emirhan Harbi, Ozcan Yildiz, Michael Aschner

引用次数: 0

Abstract

Pheochromocytoma and paraganglioma are neuroendocrine tumours characterised by excessive catecholamine release. Minoxidil, a potent vasodilator commonly used for hypertension and androgenetic alopecia, may exacerbate cardiovascular complications associated with pheochromocytoma due to its mechanisms-of-action. This commentary aims to elucidate the potential risks and safety concerns associated with the use of minoxidil in patients with pheochromocytoma. Here, we discuss the need for careful prescribing practices when considering minoxidil in pheochromocytoma-associated hypertension and the potential problems that minoxidil use may cause in pheochromocytoma patients.

查看原文本刊更多论文

米诺地尔治疗嗜铬细胞瘤和副神经节瘤的潜在风险：安全问题和机制评论。

嗜铬细胞瘤和副神经节瘤是神经内分泌肿瘤，其特征是过量的儿茶酚胺释放。米诺地尔是一种有效的血管扩张剂，通常用于高血压和雄激素性脱发，由于其作用机制，可能加剧与嗜铬细胞瘤相关的心血管并发症。本评论旨在阐明与嗜铬细胞瘤患者使用米诺地尔相关的潜在风险和安全问题。在这里，我们讨论在考虑米诺地尔治疗嗜铬细胞瘤相关性高血压时需要谨慎的处方实践，以及米诺地尔在嗜铬细胞瘤患者中使用可能引起的潜在问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.