{"title":"Origin of homochirality in terrestrial biology.","authors":"Koji Tamura","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Recent analysis of samples from asteroids Ryugu and Bennu did not reveal any significant amino acid enantiomeric excesses, and these facts appear to contradict the most prevailing view that a slight enantiomeric excess of L-amino acids present on the primitive Earth is the origin of homochirality. From the perspective of continuity in biological evolution, it would again be considered a strong possibility that primordial tRNA aminoacylation could have led to preferential homochiral (L-) protein biosynthesis on the early Earth (Tamura- Schimmel model), and that RNA played a major role in the generation of amino acid homochirality. The results of recent molecular dynamics simulations have also clarified the mechanism of its chiral selectivity.</p>","PeriodicalId":15171,"journal":{"name":"Journal of Biosciences","volume":"50 ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biosciences","FirstCategoryId":"99","ListUrlMain":"","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Recent analysis of samples from asteroids Ryugu and Bennu did not reveal any significant amino acid enantiomeric excesses, and these facts appear to contradict the most prevailing view that a slight enantiomeric excess of L-amino acids present on the primitive Earth is the origin of homochirality. From the perspective of continuity in biological evolution, it would again be considered a strong possibility that primordial tRNA aminoacylation could have led to preferential homochiral (L-) protein biosynthesis on the early Earth (Tamura- Schimmel model), and that RNA played a major role in the generation of amino acid homochirality. The results of recent molecular dynamics simulations have also clarified the mechanism of its chiral selectivity.
期刊介绍:
The Journal of Biosciences is a quarterly journal published by the Indian Academy of Sciences, Bangalore. It covers all areas of Biology and is the premier journal in the country within its scope. It is indexed in Current Contents and other standard Biological and Medical databases. The Journal of Biosciences began in 1934 as the Proceedings of the Indian Academy of Sciences (Section B). This continued until 1978 when it was split into three parts : Proceedings-Animal Sciences, Proceedings-Plant Sciences and Proceedings-Experimental Biology. Proceedings-Experimental Biology was renamed Journal of Biosciences in 1979; and in 1991, Proceedings-Animal Sciences and Proceedings-Plant Sciences merged with it.