The Interaction Between Microbiota and Stem Cells on Progression of Osteoarthritis and Engineered Stem Cell for Enhancing Osteoarthritis Treatment.

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2025-03-13 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S511884

Sidan Wang, Haotian Fu, Zheng Xu, Chunhong Huang

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引用次数: 0

Abstract

Osteoarthritis (OA) is characterized by the degeneration of articular cartilage caused by several factors of which novel most trends include microbiota. Specific microbiota and the role in the development of OA is less clear. The microbiota is presumed to influence OA occurrence and progression mainly via immune modulation. In recent years, bone marrow mesenchymal stem cells (MSCs) have shown great potential for the treatment of OA, however, the therapeutic efficiency has been seriously affected by the harsh microenvironment in the joint cavity. At present, many strategies have been used to enhance the function of MSCs, among them, engineering are a promising method. Therefore, this review mainly focuses on the latest research on how the microbiota affects the development of OA, stem cell repair, and the use of engineered MSCs in the treatment of OA. In addition, engineered MSCs can enhance the therapeutic potential of exosomes as a novel strategy for treating OA. Our review provides a comprehensive perspective on the role of microbiota in OA and the influence of MSCs therapy and engineered MSCs on the treatment of OA.

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微生物群与干细胞在骨关节炎进展中的相互作用及工程化干细胞增强骨关节炎治疗。

骨关节炎（OA）的特点是由多种因素引起的关节软骨退行性变，其中大多数新的趋势包括微生物群。具体的微生物群及其在OA发展中的作用尚不清楚。微生物群被认为主要通过免疫调节影响OA的发生和进展。近年来，骨髓间充质干细胞（MSCs）在骨性关节炎的治疗中显示出巨大的潜力，但关节腔内恶劣的微环境严重影响了其治疗效果。目前，许多方法被用于增强间充质干细胞的功能，其中工程化是一种很有前途的方法。因此，本文主要就微生物群如何影响OA的发展、干细胞修复以及工程化MSCs在OA治疗中的应用等方面的最新研究进展进行综述。此外，工程MSCs可以增强外泌体的治疗潜力，作为治疗OA的新策略。本文综述了微生物群在OA中的作用，以及MSCs治疗和工程化MSCs对OA治疗的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.