Progress of Induced Pluripotent Stem Cell-Derived Renal Organoids in Clinical Application.

IF 3.2 4区 医学 Q1 UROLOGY & NEPHROLOGY
Kidney Diseases Pub Date : 2024-11-11 eCollection Date: 2025-01-01 DOI:10.1159/000541919
Na Ning, Zhiting Liu, Xinyu Li, Yi Liu, Wei Song
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引用次数: 0

Abstract

Background: Kidney disease has become a growing public health problem worldwide, and there is an urgent need to develop reliable models for investigating novel and effective treatment strategies. In recent years, kidney organoids, as novel models different from traditional two-dimensional cells and model animals, have attracted more and more attention. Current advances have allowed the generation of kidney organoids from the directed differentiation of induced pluripotent stem cells (iPSCs), which possess similar characteristics to embryonic stem cells, but bypass ethical constraints and have a wide range of sources.

Summary: Herein, the methods of generating renal organoids from iPSCs, the applications of iPSC-derived renal organoids in disease modeling, drug effectiveness detection, and regenerative medicine as well as the challenges were reviewed.

Key messages: iPSC-derived renal organoids can be used to model kidney diseases and are great models for studying kidney injury and toxicity. Many efforts are needed to finally apply organoids into clinical application.

诱导多能干细胞衍生的肾脏器官组织在临床应用中的进展。
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来源期刊
Kidney Diseases
Kidney Diseases UROLOGY & NEPHROLOGY-
CiteScore
6.00
自引率
2.70%
发文量
33
审稿时长
27 weeks
期刊介绍: ''Kidney Diseases'' aims to provide a platform for Asian and Western research to further and support communication and exchange of knowledge. Review articles cover the most recent clinical and basic science relevant to the entire field of nephrological disorders, including glomerular diseases, acute and chronic kidney injury, tubulo-interstitial disease, hypertension and metabolism-related disorders, end-stage renal disease, and genetic kidney disease. Special articles are prepared by two authors, one from East and one from West, which compare genetics, epidemiology, diagnosis methods, and treatment options of a disease.
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