Mycobacterium heraklionense hand tenosynovitis-a case description of a three-year treatment course and perioperative measurement of azithromycin target tissue concentrations.

IF 4.1 2区 医学 Q2 MICROBIOLOGY
Mads Kristian Duborg Mikkelsen, Andrea René Jørgensen, Victor Naestholt Dahl, Christian Morberg Wejse, Mats Bue, Maiken Stilling
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引用次数: 0

Abstract

In a Mycobacterium heraklionense tenosynovitis case, we observed that azithromycin-loaded calcium sulfate beads placed in the surgical wound had minimal systemic absorption and achieved over 100-fold higher target tissue concentrations than a systemic azithromycin-based treatment regimen alone. However, continued excessive wound drainage necessitated surgical removal of the beads. While systemic antibiotics and surgery remain central to nontuberculous mycobacterial treatment, the role of local antibiotic administration in reducing the bacterial burden warrants further investigation.

赫拉克lionense支杆菌手部腱鞘炎-一个三年疗程的病例描述和围手术期阿奇霉素靶组织浓度的测量。
在一例黑克lionense分枝杆菌腱鞘炎病例中,我们观察到,将装有阿奇霉素的硫酸钙珠放置在手术伤口中,其全身吸收最小,目标组织浓度比单独使用阿奇霉素的全身治疗方案高100倍以上。然而,持续过度的伤口引流需要手术去除珠子。虽然全身抗生素和手术仍然是非结核性分枝杆菌治疗的核心,但局部抗生素给药在减少细菌负担方面的作用值得进一步研究。
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来源期刊
CiteScore
10.00
自引率
8.20%
发文量
762
审稿时长
3 months
期刊介绍: Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.
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