Valappan Veetil Soumya, Baby Jisna, Davis Anu, Chevookaren Francis Binoy, Thekkekara Devassy Babu
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引用次数: 0
Abstract
The endoplasmic reticulum (ER) plays a crucial part in protein synthesis, folding and quality control. Disruptions in these processes lead to ER stress (ERS) and activate the unfolded protein response (UPR) to restore cellular homeostasis. In gastrointestinal cancers, inositol-requiring enzyme 1α (IRE1α) is a key regulator of the UPR, helping cancer cells adapt to hostile conditions such as hypoxia, oxidative stress and chemotherapy. Elevated IRE1α activity supports tumor survival, progression and metastasis by mitigating ERS-induced apoptosis. However, targeting IRE1α signaling presents a promising therapeutic strategy, potentially impairing cancer cell adaptation to stress and enhancing treatment efficacy. Targeting IRE1α offers promising therapeutic opportunities for gastrointestinal cancer.
期刊介绍：
Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed.
Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.
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