RASSF1A loss in ccRCC: genomic instability and the role of chromosome 3p

Abstract

Clear cell renal cell carcinoma is characterized by the loss of chromosome 3p, which includes several tumor suppressor genes (e.g., VHL, PBRM1, SETD2, and BAP1) as well as RASSF1a, a frequently inactivated gene in many cancers. This commentary highlights work by Catalano et al., which explores the functional consequences of Ras association domain family 1, isoform A (RASSF1A) loss in kidney epithelial cells and calls for further research to investigate the impacts of 3p loss to uncover new therapeutic targets for clear cell renal cell carcinoma.