Preparation and properties of Baicalein loaded sodium alginate/polyvinyl alcohol nanofiber antibacterial wound dressing

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-03-17 DOI:10.1016/j.matlet.2025.138408

Yexiong Qi , Peiyu Wang , Qingchen Lu , Zena Zhou , Yanhui Hu

引用次数: 0

Abstract

Bacterial infection is an essential factor affecting wound healing, which seriously hinders the process of wound healing. Developing a medical dressing loaded with traditional Chinese medicine ingredients is an effective way to promote wound healing. In this paper, we developed a Sodium alginate/polyvinyl alcohol (SA/PVA) nanofiber containing Baicalein (Ba) by electrospinning for medical dressings. Baicalein contains hydroxyl groups, which gives the prepared nanofibers uniform diameter, good hydrophilicity and high thermal stability. The results of in vitro experiments showed that the inhibition rate of 15%Ba/SA/PVA nanofiber against S. aureus and E. coli were 98.86% and 99.58%, respectively. Moreover, the drug release rate of 15%Ba/SA/PVA nanofiber was 78%. This drug-loaded nanofiber has a massive potential as an excellent antibacterial dressing for wound healing.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive