{"title":"What's old is new again: opioid and benzodiazepine actions on ventilation, a reminder of the importance of knowing one's drugs","authors":"Konrad Meissner , Evan D. Kharasch","doi":"10.1016/j.bja.2025.01.014","DOIUrl":null,"url":null,"abstract":"<div><div>Co-administering opioids and benzodiazepines can have deleterious effects on ventilation. However, little is known about the underlying mechanisms leading to hypoventilation. A recent article in the <em>British Journal of Anaesthesia</em> is not just another reminder of the hazards of combining opioids with benzodiazepines or other sedatives, but also applies mechanistic understanding to guide informed practice and future pharmaceutical development.</div></div>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"134 4","pages":"Pages 903-905"},"PeriodicalIF":9.1000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of anaesthesia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0007091225000273","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Co-administering opioids and benzodiazepines can have deleterious effects on ventilation. However, little is known about the underlying mechanisms leading to hypoventilation. A recent article in the British Journal of Anaesthesia is not just another reminder of the hazards of combining opioids with benzodiazepines or other sedatives, but also applies mechanistic understanding to guide informed practice and future pharmaceutical development.
期刊介绍:
The British Journal of Anaesthesia (BJA) is a prestigious publication that covers a wide range of topics in anaesthesia, critical care medicine, pain medicine, and perioperative medicine. It aims to disseminate high-impact original research, spanning fundamental, translational, and clinical sciences, as well as clinical practice, technology, education, and training. Additionally, the journal features review articles, notable case reports, correspondence, and special articles that appeal to a broader audience.
The BJA is proudly associated with The Royal College of Anaesthetists, The College of Anaesthesiologists of Ireland, and The Hong Kong College of Anaesthesiologists. This partnership provides members of these esteemed institutions with access to not only the BJA but also its sister publication, BJA Education. It is essential to note that both journals maintain their editorial independence.
Overall, the BJA offers a diverse and comprehensive platform for anaesthetists, critical care physicians, pain specialists, and perioperative medicine practitioners to contribute and stay updated with the latest advancements in their respective fields.