Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-03-18 DOI:10.1016/j.gde.2025.102329

Longzhi Tan , X. Sunney Xie , Stavros Lomvardas

引用次数: 0

Abstract

Olfactory receptor (OR) gene choice, the stable expression of one out of >2000 OR alleles by olfactory sensory neurons, constitutes a gene regulatory process that is driven by three-dimensional nuclear architecture. Moreover, the differentiation-dependent process that culminates in monogenic and monoallelic OR transcription represents a powerful demonstration of the rich mechanistic insight that single-cell genomics and multiomics can provide toward the understanding of a biological process. At this review, we describe the latest advances in the understanding of OR gene regulation and highlight important standing questions regarding the emerging specificity of ultra-long-range genomic interaction and the contribution of transcription and noncoding RNAs.

查看原文本刊更多论文

基因组雪花：DNA折叠的独特性如何让我们闻到化学宇宙

嗅觉受体（Olfactory receptor， OR）基因选择是嗅觉感觉神经元在2000个OR等位基因中稳定表达一个的过程，是一个由三维核结构驱动的基因调控过程。此外，以单基因和单等位基因OR转录为高潮的分化依赖过程有力地证明了单细胞基因组学和多组学可以为理解生物过程提供丰富的机制见解。在这篇综述中，我们描述了在理解OR基因调控方面的最新进展，并强调了关于超远程基因组相互作用的新特异性以及转录和非编码rna的贡献的重要问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)