The Cytoprotective and Antioxidant Effects of Resveratrol on Human Lymphocytes Modified with Hydrogen Peroxide and UV Light

Abstract

A decrease in the intensity of the processes of apoptotic and necrotic death of human peripheral blood lymphocytes was found after exposure to UV light (254 nm, 1510 J/m²) and hydrogen peroxide (10^–5 mol/L) in the presence of resveratrol (10^–7, 10^–6, 10^–5 mol/L). It was revealed that the cytoprotective effect of resveratrol on lymphocytes is due to a decrease in the level of production of intracellular reactive oxygen species and calcium ions, an increase in the activity of antioxidant enzymes, that is, catalase and glutathione reductase, an increase in peroxide resistance of plasma membranes, and interaction with DNA. Possible mechanisms of action of resveratrol as a regulator of the processes of apoptotic and necrotic death of lymphocytes induced by exposure to hydrogen peroxide and UV radiation are discussed.