The Effect of Dinitrosyl Iron Complexes with a Ligand Based on N-acethyl-L-cysteine upon Inhalation Delivery of These Complexes into the Body of Rats

Abstract

The aim of the work was to study the effect of dinitrosyl iron complexes (DNIC) with a ligand based on N-acetyl-L-cysteine upon its prolonged administration into the rat body by inhalation. It was found that as a result of this, an effective transfer of stabilized forms of NO occurred through the alveolar wall into the lung tissue. Accumulation of dinitrosyl iron complexes with protein ligands in the lungs and other organs, an increase in their total NO level, as well as a significant and prolonged hypotensive effect were observed.