Novel Organotin Complexes with Losartan: Synthesis and Biological Activity

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2025-03-18 DOI:10.1134/S1990750824601334

T. A. Antonenko, O. A. Raykova, Yu. A. Gracheva, D. M. Mazur, V. A. Roznyatovsky, R. I. oglu Musaev, N. A. Gurova, M. S. Pshenichnikova, D. S. Yakovlev, E. R. Milaeva, A. A. Spasov

引用次数: 0

Abstract

Novel organotin(IV) complexes based on losartan have been synthesized and characterized by ¹H, ¹³C, ¹¹⁹Sn NMR, IR, ESI-MS and elemental analysis. The antiproliferative activity of the complexes was assessed in vitro against human cancer cells, while their cytotoxic effects were examined on primary rat skin fibroblasts. The compounds exhibited strong activity, significantly inducing apoptosis. Additionally, they effectively suppressed the spasmogenic effect induced by angiotensin II in isolated rat portal veins.

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来源期刊

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

1.10

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0.00%

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期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.