Severe Acute Respiratory Syndrome Coronavirus 2 Immunology and Coronavirus Disease 2019 Clinical Outcomes.

IF 6.1 3区医学 Q1 IMMUNOLOGY

Infectious disease clinics of North America Pub Date : 2025-03-14 DOI:10.1016/j.idc.2025.02.001

Aljawharah Alrubayyi, Hsinyen Huang, Gaurav D Gaiha

引用次数: 0

Abstract

The humoral and cellular immune response are the key players in preventing viral infection and limiting disease severity, particular in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019. In this review, we discuss how immune responses generated by prior infection and vaccination influence the outcomes of SARS-CoV-2 infection. We aim to provide an overview of the role of humoral and cellular immunity, with a particular focus on CD8⁺ T cell responses, to delineate how different immune compartments contribute to the control of infection and modulation of disease outcomes.

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来源期刊

Infectious disease clinics of North America 医学-传染病学

CiteScore

8.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Infectious Disease Clinics of North America updates you on the latest trends in the clinical diagnosis and management of patients with infectious diseases, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in infectious disease, including clinical microbiology, compromised host infections, gastrointestinal infections, global health, hepatitis, HIV/AIDS, hospital-acquired infections, travel medicine, infection control, bacterial infections, sexually transmitted diseases, urinary tract infections, and viral infections.