Boosting mRNA-Engineered Monocytes via Prodrug-Like Microspheres for Bone Microenvironment Multi-Phase Remodeling (Adv. Healthcare Mater. 7/2025)

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-03-17 DOI:10.1002/adhm.202570044

Yuansheng Wu, Yingjie Zhu, Jie Chen, Lili Song, Chunping Wang, Yanglin Wu, Yanyang Chen, Jiancheng Zheng, Yuankun Zhai, Xiang Zhou, Youwen Liu, Yawei Du, Wenguo Cui

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引用次数: 0

Abstract

Injectable mRNA Microplexes

In article 2403212, Youwen Liu, Yawei Du, Wenguo Cui, and co-workers introduce an injectable microplex system that combines IL-4 mRNA lipid nanoparticles (LNPs) with icariin prodrug-like microspheres to achieve in-situ regulation of monocytes for tissue regeneration. The prodruglike microspheres enable the sustained release of both icariin and LNPs, facilitating multi-phase remodeling of the osteoclastic microenvironment and effective monocyte engineering. This innovative injectable mRNA microplex system successfully addresses the challenges of bone defect repair caused by inflammation and excessive osteoclast activity.

Abstract Image

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通过类原药微球增强 mRNA 工程化单核细胞，实现骨微环境多相重塑（Adv.）

在文章2403212中，刘有文、杜亚伟、崔文国等人介绍了一种可注射的microplex系统，该系统将IL-4 mRNA脂质纳米颗粒（LNPs）与淫羊藿苷前药样微球结合，实现原位调控单核细胞的组织再生。前药物样微球能够持续释放淫羊藿苷和LNPs，促进破骨细胞微环境的多期重塑和有效的单核细胞工程。这种创新的可注射mRNA微丛系统成功地解决了由炎症和过度破骨细胞活性引起的骨缺损修复的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.