Effect of the Extraction Method and Conditions on the Content of Polyphenols in Buckwheat Fagopyrum esculentum Husk Extracts and Their Acetylcholinesterase-Inhibiting Activity

IF 1.4 4区化学 Q4 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

Russian Journal of Physical Chemistry B Pub Date : 2025-03-16 DOI:10.1134/S1990793124701744

S. S. Khizrieva, S. N. Borisenko, E. V. Maksimenko, A. V. Ippolitova, K. O. Shchedrina, N. I. Borisenko, V. I. Minkin

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Abstract

The effect of the extraction method and conditions on the polyphenolic composition of buckwheat Fagopyrum esculentum husk extracts and their activity in inhibiting acetylcholinesterase (AChE) was studied. The extracts were obtained both by the conventional method of water–ethanol extraction and in a subcritical water medium at 120–220°C. A direct correlation was found between the anticholinesterase activity and the content of polyphenols in the extracts. The highest activity in inhibiting AChE was shown by the extract obtained in the subcritical water medium at 220°C, which contained the maximum amounts of polyphenols and flavonoids. This indicates the decisive role of these compounds in inhibiting AChE. The obtained data allow one to consider buckwheat husk extracts as inexpensive and renewable sources of polyphenolic compounds and flavonoids with P-vitamin and neuroprotective activity.

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研究了提取方法和条件对荞麦壳提取物中多酚成分及其抑制乙酰胆碱酯酶（AChE）活性的影响。萃取物通过传统的水乙醇萃取法和在 120-220°C 的亚临界水介质中获得。研究发现，抗胆碱酯酶活性与提取物中多酚的含量直接相关。在 220°C 的亚临界水介质中提取的提取物对 AChE 的抑制活性最高，其中含有最多的多酚和类黄酮。这表明这些化合物在抑制 AChE 方面起着决定性作用。根据所获得的数据，我们可以认为荞麦壳提取物是廉价且可再生的多酚化合物和类黄酮来源，具有维生素P和神经保护活性。

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来源期刊

Russian Journal of Physical Chemistry B 化学-物理：原子、分子和化学物理

CiteScore

2.20

自引率

71.40%

发文量

106

审稿时长

4-8 weeks

期刊介绍： Russian Journal of Physical Chemistry B: Focus on Physics is a journal that publishes studies in the following areas: elementary physical and chemical processes; structure of chemical compounds, reactivity, effect of external field and environment on chemical transformations; molecular dynamics and molecular organization; dynamics and kinetics of photoand radiation-induced processes; mechanism of chemical reactions in gas and condensed phases and at interfaces; chain and thermal processes of ignition, combustion and detonation in gases, two-phase and condensed systems; shock waves; new physical methods of examining chemical reactions; and biological processes in chemical physics.