An update of systemic analgesics in children

IF 0.2 Q4 ANESTHESIOLOGY

Anaesthesia and Intensive Care Medicine Pub Date : 2025-03-01 DOI:10.1016/j.mpaic.2024.12.006

Katherine Pixley Smith, Alok Chauhan

引用次数: 0

Abstract

Paediatric pain is often poorly recognized and undertreated, and managing it effectively can be complex and challenging. Exposure to severe pain without adequate management in childhood can be detrimental and is associated with adverse long-term outcomes such as chronic pain, anxiety and depressive disorders later in life. A multimodal analgesic regimen is recommended, and is just one aspect of a multi-faceted approach to paediatric pain management.

The aim of this review is to highlight systemic analgesic options for children, including important considerations for neonates. A range of drugs are discussed, focussing on pharmacokinetic and pharmacodynamic features, as well as their potential adverse side effects and risks.

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儿科疼痛往往不易察觉且治疗不足，而有效管理儿科疼痛可能非常复杂且具有挑战性。童年时期遭受剧烈疼痛而得不到适当的治疗可能会带来不利影响，并与长期不良后果相关，如日后的慢性疼痛、焦虑和抑郁障碍。本综述旨在强调儿童系统性镇痛的选择，包括新生儿的重要注意事项。本文讨论了一系列药物，重点是药代动力学和药效学特征及其潜在的不良副作用和风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaesthesia and Intensive Care Medicine ANESTHESIOLOGY-

CiteScore

0.50

自引率

0.00%

发文量

152

期刊介绍： Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.