Distance matters: How protein regulators facilitate enhancer-promoter interactions and transcription.

Abstract

Cohesin, transcription factors (TFs), and mediator complex components regulate gene expression partly by regulating enhancer-promoter (E-P) communication. A new study combined E-P distance-controlled reporter screens with the inhibition or degradation of regulatory proteins and uncovered a distance-dependent effect across cohesin, TFs, and mediator complex components.