Catalytic Atroposelective Electrophilic Amination to Access Axially Chiral Diaryl Phenols.

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2025-03-13 DOI:10.1002/asia.202500239

Ying Shao, Han Wang, Qiang Chen, Shengbiao Tang, Jiangtao Sun

引用次数: 0

Abstract

An enantioselective synthesis of axially chiral diaryl phenols containing sulfonamide groups has been achieved involving an electrophilic amination of 1,1'-biaryl-2,6-diols with N-sulfonyl quinone diimines, catalyzed by a chiral phosphoric acid. This atroposelective reaction offers a modular approach to enantiopure diaryl phenols, with good-to-excellent yields.

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催化亲电胺化反应制备轴手性二芳基苯酚。

用手性磷酸催化1,1′-二芳基-2,6-二醇与n -磺酰基醌二亚胺的亲电胺化反应，实现了含有磺酰胺基团的轴向手性二芳基苯酚的对映选择性合成。该反应为对映纯二芳基酚提供了一种模块化的方法，收率高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).