Metastatic adenocarcinoma: a case report of multiple primary tumors in the oral cavity

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.058

Juliana Meneses Montalvão Costa, Liliana Wolf Braun, Thais Lins Soares Leite, Luis Afonso Tochetto, Marco Antonio Trevizani Martins, Vinicius Coelho Carrard, Manoela Domingues Martins

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引用次数: 0

Abstract

A 59-year-old male patient was referred to the oral medicine department because of persistent sialorrhea and dysphagia resulting from squamous cell carcinoma of the esophagus that was treated with radiotherapy in 2021. The patient was taking omeprazole 20 mg daily and denied smoking or alcohol consumption regularly. During evaluation, a hard asymptomatic nodule was identified on the right lateral border of the patient's tongue. An incisional biopsy revealed adenosquamous carcinoma, and the patient underwent partial glossectomy with supraomohyoid neck dissection. Two months later, the patient developed a hard submucosal nodule on the lower lip, which was diagnosed as conventional polymorphic adenocarcinoma. Metastatic lesions of polymorphic adenocarcinoma were also detected in the right temporal region, eyebrow, and upper and lower lips. Palliative chemotherapy was recommended, consisting of 8 cycles of carboplatin AUC 5 and paclitaxel 175 mg/m² administered every 21 days, followed by the FOLFOX (leucovorin, fluorouracil, and oxaliplatin) second-line chemotherapy protocol.

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.