{"title":"The PREPARED Case Study App for deep reflection on research ethics challenges during crises","authors":"Doris Schroeder, Nearchos Paspallis, Nicos Kasenides, Kate Chatfield, Carly Seedall, Michelle Singh","doi":"10.1038/s41591-025-03549-2","DOIUrl":null,"url":null,"abstract":"<p>Allegiance to the Hippocratic Oath was once considered sufficient to ensure ethical conduct in medicine and health care. But in today’s world, healthcare professionals face unprecedented ethical dilemmas<sup>1</sup>, from navigating mandatory COVID-19 vaccinations to addressing systemic racism in clinical care<sup>2</sup>. Simultaneously, the systematic practice of medical research has a history that spans only about 300 years<sup>3</sup>, which has left room for evolution in ethical standards and practices.</p><p>One response to the challenge of new ethical dilemmas is new ethics guidance. For instance, during the COVID-19 pandemic, hundreds of new ethics codes and guidance documents were issued around the world in English alone<sup>4</sup>.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"19 1","pages":""},"PeriodicalIF":58.7000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41591-025-03549-2","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Allegiance to the Hippocratic Oath was once considered sufficient to ensure ethical conduct in medicine and health care. But in today’s world, healthcare professionals face unprecedented ethical dilemmas1, from navigating mandatory COVID-19 vaccinations to addressing systemic racism in clinical care2. Simultaneously, the systematic practice of medical research has a history that spans only about 300 years3, which has left room for evolution in ethical standards and practices.
One response to the challenge of new ethical dilemmas is new ethics guidance. For instance, during the COVID-19 pandemic, hundreds of new ethics codes and guidance documents were issued around the world in English alone4.
期刊介绍:
Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors.
Nature Medicine consider all types of clinical research, including:
-Case-reports and small case series
-Clinical trials, whether phase 1, 2, 3 or 4
-Observational studies
-Meta-analyses
-Biomarker studies
-Public and global health studies
Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.