Critical role of ferroptosis in viral infection and host responses

Abstract

Ferroptosis is an iron-dependent form of programmed cell death that plays a crucial role in regulating intracellular redox homeostasis and lipid metabolism, and in combating viral infections. Viruses have persistently evolved and adapted synergistically with their hosts over a long period and, to some extent, have been able to utilize ferroptosis to promote viral replication. Herein, we summarize the characteristics, mechanisms, and regulatory networks of ferroptosis and provide an overview of the key regulatory steps of ferroptosis involved in viral infection, together with the changes in host indicators and key regulatory signaling pathways. This study intends to deepen our understanding of the critical role of ferroptosis in viral infection, which will be meaningful for further revealing the mechanisms underlying the occurrence and progression of virus diseases, as well as for the future exploration of anti-viral strategies.