Metastatic neuroendocrine carcinoma of the small intestine presenting as temporomandibular disorder

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of the American Dental Association Pub Date : 2025-04-01 DOI:10.1016/j.adaj.2025.02.008

Shaiba Sandhu DDS, MS, Sonya Kalim DMD, MS, Demetria Ileana Strauch Jacks MD, Muhammad Ali Shazib DMD

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引用次数: 0

Abstract

Background

Neuroendocrine carcinomas (NECs) are rare tumors from hormone-secreting neuroendocrine cells, often within the gastrointestinal tract. The authors report what is, to their best knowledge, the first case of a small intestine NEC metastasizing to the temporomandibular joint (TMJ).

Case Description

A 60-year-old man came to the oral medicine, oncology, and orofacial pain clinic with a chief concern of left-sided jaw pain. Clinical examination revealed left TMJ arthralgia and deep masseter myalgia, and results of imaging showed both osteoblastic and osteolytic changes in the left TMJ. A comprehensive diagnostic approach, including detailed history, clinical evaluation, and advanced imaging techniques, such as positron emission tomography computed tomography, was used to establish an accurate diagnosis.

Practical Implications

This case highlights the importance of considering metastasis in differential diagnosis of TMJ pain in patients with NEC, underscoring collaboration between oncology and orofacial pain specialists for accurate diagnosis and effective management.

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小肠转移性神经内分泌癌表现为颞下颌关节紊乱。

背景：神经内分泌癌（NECs）是一种罕见的由分泌激素的神经内分泌细胞引起的肿瘤，通常发生在胃肠道内。作者报告了他们所知的第一例小肠NEC转移到颞下颌关节（TMJ）的病例。病例描述：一名60岁男性来到口腔医学、肿瘤学和口腔面部疼痛诊所，主要关注左侧颌骨疼痛。临床检查显示左侧TMJ关节痛和深咬肌痛，影像学显示左侧TMJ成骨和溶骨改变。全面的诊断方法，包括详细的病史，临床评估和先进的成像技术，如正电子发射断层扫描计算机断层扫描，用于建立准确的诊断。实际意义：本病例强调了在NEC患者TMJ疼痛鉴别诊断中考虑转移的重要性，强调了肿瘤学和口腔面部疼痛专家之间的合作，以准确诊断和有效管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Dental Association 医学-牙科与口腔外科

CiteScore

5.30

自引率

10.30%

发文量

221

审稿时长

34 days

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