{"title":"Antibiotic resistance and molecular characterization of clinical Shigella spp. isolated from hospitals located in Tehran and Qazvin cities, Iran.","authors":"Termeh Raoufian, Babak Pakbin, Akram Sadat Tabatabaee Bafroee","doi":"10.1186/s13104-025-07113-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This research aims to investigate the epidemiology and genetic changes of Shigella species in the cities of Qazvin and Tehran from 2003 to 2023, with a focus on assessing antibiotic resistance among the isolates. This study is based on the analysis of 80 Shigella isolates, which were obtained from patients' feces.</p><p><strong>Results: </strong>Using pulsed-field gel electrophoresis (PFGE) as the primary typing method, the isolates were classified into 13 distinct clusters, revealing a dominant pattern that has persisted for over twenty years. This persistence may be attributed to factors such as poor hygiene, personal contact, immigration, and antibiotic resistance. Genetic analysis indicated clonal expansion among the isolates over the two-decade period. Notably, the highest resistance was observed against amoxicillin, with several isolates exhibiting multidrug resistance.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"110"},"PeriodicalIF":1.6000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899193/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Research Notes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13104-025-07113-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This research aims to investigate the epidemiology and genetic changes of Shigella species in the cities of Qazvin and Tehran from 2003 to 2023, with a focus on assessing antibiotic resistance among the isolates. This study is based on the analysis of 80 Shigella isolates, which were obtained from patients' feces.
Results: Using pulsed-field gel electrophoresis (PFGE) as the primary typing method, the isolates were classified into 13 distinct clusters, revealing a dominant pattern that has persisted for over twenty years. This persistence may be attributed to factors such as poor hygiene, personal contact, immigration, and antibiotic resistance. Genetic analysis indicated clonal expansion among the isolates over the two-decade period. Notably, the highest resistance was observed against amoxicillin, with several isolates exhibiting multidrug resistance.
BMC Research NotesBiochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
3.60
自引率
0.00%
发文量
363
审稿时长
15 weeks
期刊介绍：
BMC Research Notes publishes scientifically valid research outputs that cannot be considered as full research or methodology articles. We support the research community across all scientific and clinical disciplines by providing an open access forum for sharing data and useful information; this includes, but is not limited to, updates to previous work, additions to established methods, short publications, null results, research proposals and data management plans.
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