Methylphenidate and P300 in attention deficit hyperactivity disorder: A systematic review and meta-analysis

IF 2.5 3区心理学 Q3 NEUROSCIENCES

International Journal of Psychophysiology Pub Date : 2025-03-08 DOI:10.1016/j.ijpsycho.2025.112553

Beatriz C. R. Barroso , Fabiana Mendonça , Prune Mazer , Catarina Prata , Joana O. Pinto

{"title":"Methylphenidate and P300 in attention deficit hyperactivity disorder: A systematic review and meta-analysis","authors":"Beatriz C. R. Barroso , Fabiana Mendonça , Prune Mazer , Catarina Prata , Joana O. Pinto","doi":"10.1016/j.ijpsycho.2025.112553","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Methylphenidate (MPH) is a stimulant medicine often used to treat attention deficit hyperactivity disorder (ADHD), as it may positively affect behaviour and brain activity. This work aims to systematise the current literature about the effects of MPH on the amplitude of P300 in individuals with ADHD.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis of empirical studies measuring P300 amplitude and comparing MPH administration to either a pre-MPH condition or healthy controls was conducted, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.</div></div><div><h3>Results</h3><div>Our results revealed no overall (<em>n</em> = 13) significant differences between individuals diagnosed with ADHD and medicated with MPH and controls. Although, a moderation analysis by region found differences between both groups on frontal sites. When comparing the pre- and post-effects of MPH on the same individuals (<em>n</em> = 17), it appears that P300 amplitude tends to increase post-administration in central and posterior regions. In this second meta-analysis, a moderation by task revealed a larger effect size for go/no-go.</div></div><div><h3>Discussion</h3><div>In general, MPH was found to increase P300 amplitude in ADHD, somewhat normalising this aspect of their brain activity. The main limitations of the included studies are the insufficiently explained dosages and the skewness for male participants. Future research directions are discussed.</div></div>","PeriodicalId":54945,"journal":{"name":"International Journal of Psychophysiology","volume":"211 ","pages":"Article 112553"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Psychophysiology","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167876025000492","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Methylphenidate (MPH) is a stimulant medicine often used to treat attention deficit hyperactivity disorder (ADHD), as it may positively affect behaviour and brain activity. This work aims to systematise the current literature about the effects of MPH on the amplitude of P300 in individuals with ADHD.

Methods

A systematic review and meta-analysis of empirical studies measuring P300 amplitude and comparing MPH administration to either a pre-MPH condition or healthy controls was conducted, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Results

Our results revealed no overall (n = 13) significant differences between individuals diagnosed with ADHD and medicated with MPH and controls. Although, a moderation analysis by region found differences between both groups on frontal sites. When comparing the pre- and post-effects of MPH on the same individuals (n = 17), it appears that P300 amplitude tends to increase post-administration in central and posterior regions. In this second meta-analysis, a moderation by task revealed a larger effect size for go/no-go.

Discussion

In general, MPH was found to increase P300 amplitude in ADHD, somewhat normalising this aspect of their brain activity. The main limitations of the included studies are the insufficiently explained dosages and the skewness for male participants. Future research directions are discussed.

查看原文本刊更多论文

哌甲酯和P300在注意缺陷多动障碍中的作用：一项系统综述和荟萃分析。

背景：哌醋甲酯（MPH）是一种兴奋剂药物，通常用于治疗注意缺陷多动障碍（ADHD），因为它可能对行为和大脑活动产生积极影响。这项工作的目的是将目前关于MPH对ADHD患者P300振幅影响的文献系统化。方法：根据系统评价和荟萃分析的首选报告项目，对测量P300振幅的实证研究进行了系统回顾和荟萃分析，并将MPH管理与MPH前状态或健康对照进行了比较。结果：我们的研究结果显示，在诊断为ADHD的个体和使用MPH治疗的个体与对照组之间，总体上没有显著差异（n = 13）。不过，按地区划分的适度研究发现了额叶部位的差异。当比较MPH对同一个体的前后影响时（n = 17），似乎P300振幅在中央和后部区域增加。在第二项荟萃分析中，任务的调节显示出“去”/“不去”的效应更大。讨论：一般来说，发现MPH增加了ADHD患者的P300振幅，在某种程度上使他们的大脑活动正常化。纳入研究的主要局限性是剂量解释不充分和男性参与者的偏倚。展望了未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Psychophysiology 医学-神经科学

CiteScore

5.40

自引率

10.00%

发文量

177

审稿时长

3-8 weeks

期刊介绍： The International Journal of Psychophysiology is the official journal of the International Organization of Psychophysiology, and provides a respected forum for the publication of high quality original contributions on all aspects of psychophysiology. The journal is interdisciplinary and aims to integrate the neurosciences and behavioral sciences. Empirical, theoretical, and review articles are encouraged in the following areas: • Cerebral psychophysiology: including functional brain mapping and neuroimaging with Event-Related Potentials (ERPs), Positron Emission Tomography (PET), Functional Magnetic Resonance Imaging (fMRI) and Electroencephalographic studies. • Autonomic functions: including bilateral electrodermal activity, pupillometry and blood volume changes. • Cardiovascular Psychophysiology:including studies of blood pressure, cardiac functioning and respiration. • Somatic psychophysiology: including muscle activity, eye movements and eye blinks.