Cover Feature: Visible-Light-Switchable Molecular Glues for Reversible Control of Protein Function (Chem. Eur. J. 15/2025)

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-03-12 DOI:10.1002/chem.202581503

Jun Zhang, Laura K. Herzog, Shuang Li, Xi Chen, Yao-Wen Wu

引用次数: 0

Abstract

Dancing with light: A chemo-optogenetic system has been developed by using azobenzene-based photoswitchable molecular glues (sMGs) to reversibly control protein dimerization/proximity in living cells. Under blue light, these molecules bring two proteins together, whereas green light causes them to separate, like a dance. This system provides a new tool for studying complex cell processes with high precision in both time and space. More information can be found in the Research Article by Y. W. Wuand co-workers (DOI: 10.1002/chem.202403808).

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与光共舞通过使用偶氮苯基光开关分子胶（sMGs）来可逆地控制活细胞中蛋白质的二聚化/接近，我们开发出了一种化学光遗传系统。在蓝光照射下，这些分子会将两个蛋白质聚集在一起，而绿光则会使它们分开，就像跳舞一样。该系统为在时间和空间上高精度地研究复杂的细胞过程提供了一种新工具。更多信息，请参阅 Y. W. Wu 及其合作者的研究文章（DOI.Wu 及其合作者的研究文章中（DOI: 10.1002/chem.202403808）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.