The CREscendoing promise of HDAC targeting to limit atherosclerosis

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-03-11 DOI:10.1016/j.immuni.2025.02.010

Máté G. Kiss, Christoph J. Binder

引用次数: 0

Abstract

The factors that modulate the inflammatory response in atherosclerosis are not well defined. In this issue of Immunity, Asare et al. examine the impact of a cis-regulatory element (CRE) that controls expression of HDAC9 and find that HDAC9-mediated deacetylation of NLRP3 might be the mechanism by which genetic variants in this conserved CRE influence the inflammation associated with human atherosclerosis.

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调节动脉粥样硬化炎症反应的因素尚未明确。在本期《免疫》杂志上，Asare 等人研究了控制 HDAC9 表达的顺式调节元件 (CRE) 的影响，发现 HDAC9 介导的 NLRP3 去乙酰化可能是这一保守的 CRE 中的遗传变异影响与人类动脉粥样硬化相关的炎症的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.