Post-Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Carly L Lancaster, Kenneth H Moberg, Anita H Corbett
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引用次数: 0

Abstract

In recent years, there has been a growing appreciation for how regulatory events that occur either co- or post-transcriptionally contribute to the control of gene expression. Messenger RNAs (mRNAs) are extensively regulated throughout their metabolism in a precise spatiotemporal manner that requires sophisticated molecular mechanisms for cell-type-specific gene expression, which dictates cell function. Moreover, dysfunction at any of these steps can result in a variety of human diseases, including cancers, muscular atrophies, and neurological diseases. This review summarizes the steps of the central dogma of molecular biology, focusing on the post-transcriptional regulation of gene expression.

基因表达的转录后调控和真核mrna的复杂生命。
近年来,越来越多的人认识到调控事件是如何共同或转录后对基因表达的控制做出贡献的。信使rna (mrna)在其整个代谢过程中以精确的时空方式受到广泛调节,这需要复杂的分子机制来控制细胞类型特异性基因表达,从而决定细胞功能。此外,这些步骤中的任何一个功能障碍都可能导致各种人类疾病,包括癌症、肌肉萎缩和神经系统疾病。本文综述了分子生物学的核心理论,重点介绍了基因表达的转录后调控。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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