Harnessing FLASH irradiation to improve immunotherapy of medulloblastoma.

IF 17.5 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI:10.1016/j.trecan.2025.02.005

María Cecilia Lira, Claire Vanpouille-Box, Mara De Martino

引用次数: 0

Abstract

Ultra-high dose delivery of radiation (>40 Gy/s), namely FLASH radiation therapy (FLASH-RT), is a novel treatment strategy that maximizes cell kill while sparing normal tissue. Recent data reported by Ni et al. demonstrate that one of the mechanisms through which FLASH-RT promotes inflammation involves the metabolic reprogramming of macrophages to support immune stimulation, thus enhancing immunotherapy in medulloblastoma (MB).

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利用FLASH照射改善髓母细胞瘤的免疫治疗。

超高剂量放射（40gy /s），即FLASH放射治疗（FLASH- rt），是一种新的治疗策略，可以最大限度地杀死细胞，同时保留正常组织。Ni等人最近报道的数据表明，FLASH-RT促进炎症的机制之一涉及巨噬细胞的代谢重编程，以支持免疫刺激，从而增强髓母细胞瘤（MB）的免疫治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.