A novel water-soluble dinuclear Pd(II) complex having 4,4'- bipyridine and diethylenetriamine ligands and its interaction with DNA and BSA.

IF 2.7 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biomolecular Structure & Dynamics Pub Date : 2025-03-07 DOI:10.1080/07391102.2025.2475386

Narjes Alisufi, Effat Dehghanian, Hassan Mansouri-Torshizi, Fatemeh Mohammadi, Leila Dehghanian

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引用次数: 0

Abstract

A novel dinuclear palladium(II) complex i.e., [{Pd(dien)}₂(µ-4,4'-bpy)]Cl₄, (dien = diethylenetriamine and bpy = bipyridine), has been synthesized and characterized by means of conductivity measurement, elemental analysis, FT-IR, 1D ¹H NMR, 2D ¹H NMR and ¹³C NMR. Binding characteristics of this complex to DNA and BSA was investigated by electronic absorption, fluorescence, electrophoresis, energy transfer, circular dichroism and cyclic voltammetry which revealed that van der Waals and hydrogen bonds are the main binding forces for the di-Pd(II) complex interaction with the mentioned biomacromolecules. The cytotoxicity assay of the di-Pd(II) complex has been performed on human acute lymphoblastic leukemia (MOLT-4) cell line. Finally, to identify DNA/BSA binding site for the metal complex, theoretical investigations were conducted utilizing molecular docking.

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通过电导率测量、元素分析、傅立叶变换红外光谱、一维 1H NMR、二维 1H NMR 和 13C NMR，合成并表征了一种新型双核钯（II）配合物，即 [{Pd（dien）}2（µ-4,4'-bpy）]Cl4（dien = 二乙烯三胺，bpy = 联吡啶）。通过电子吸收、荧光、电泳、能量转移、圆二色性和循环伏安法研究了该复合物与 DNA 和 BSA 的结合特性，结果表明范德华和氢键是二钯(II)复合物与上述生物大分子相互作用的主要结合力。在人类急性淋巴细胞白血病（MOLT-4）细胞系上进行了二钯(II)复合物的细胞毒性试验。最后，为了确定金属复合物的 DNA/BSA 结合位点，利用分子对接进行了理论研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomolecular Structure & Dynamics 生物-生化与分子生物学

CiteScore

8.90

自引率

9.10%

发文量

597

审稿时长

2 months

期刊介绍： The Journal of Biomolecular Structure and Dynamics welcomes manuscripts on biological structure, dynamics, interactions and expression. The Journal is one of the leading publications in high end computational science, atomic structural biology, bioinformatics, virtual drug design, genomics and biological networks.