Recent Advances of Nitrobenzoselenadiazole for Imaging and Therapy

IF 8.2 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors Pub Date : 2025-03-10 DOI:10.1021/acssensors.4c03596

Jong Min An, Yeon Jin Lim, Seung Geun Yeo, Yun Hak Kim, Dokyoung Kim

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Abstract

The development and practical applications of multifunctional organic fluorophores have garnered significant attention in translational research in recent years. Among the fluorophores, nitrobenzodioxazole (NBD) has been widely used in various fields due to its small size and neutral character, both of which are advantageous for biorelated applications. However, NBD presents some limitations, including (1) suboptimal photophysical properties for in vivo applications and (2) its monofunctional nature, which restricts its use in fluorescence-based bioimaging and sensing. To overcome these challenges, recent research has focused on the development of nitrobenzoselenadiazole (NBSD) derivatives, a selenium analog of NBD. In this review article, we systematically summarize recent advancements in the development of NBSD and highlight examples of its application in translational research as a multifunctional organic fluorophore. We also explore the potential applications of NBSD and present representative case studies, providing valuable context for the ongoing development of new NBSD derivatives in the field of fluorophore-related material science.

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来源期刊

ACS Sensors Chemical Engineering-Bioengineering

CiteScore

14.50

自引率

3.40%

发文量

372

期刊介绍： ACS Sensors is a peer-reviewed research journal that focuses on the dissemination of new and original knowledge in the field of sensor science, particularly those that selectively sense chemical or biological species or processes. The journal covers a broad range of topics, including but not limited to biosensors, chemical sensors, gas sensors, intracellular sensors, single molecule sensors, cell chips, and microfluidic devices. It aims to publish articles that address conceptual advances in sensing technology applicable to various types of analytes or application papers that report on the use of existing sensing concepts in new ways or for new analytes.