Effect of the Combination of Hemodialysis and

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY

Iranian journal of kidney diseases Pub Date : 2025-02-25 DOI:10.52547/g1yt6d73

引用次数: 0

Abstract

Introduction: Uremic pruritus (UP) is a disturbing symptom in a quite large proportion of hemodialysis (HD) patients. Recent studies have indicated a potential role of interleukin-31 (IL-31) in the pathophysiology of pruritus, and it is becoming a promising therapeutic target for

查看原文本刊更多论文

血液透析联合血液灌流对清除白细胞介素-31的影响：一项维持性血液透析患者的前瞻性、随机交叉试验

导读：尿毒症性瘙痒（UP）是相当大比例血液透析（HD）患者的困扰症状。最近的研究表明，白细胞介素-31 （IL-31）在瘙痒症的病理生理中具有潜在的作用，它正在成为UP的一个有希望的治疗靶点。血液灌流（HP）是一种体外技术，已被证明在吸收可能导致瘙痒的分子方面是有效的。在这项研究中，我们进行了这项研究，以探讨额外的HP是否可以增强UP患者IL-31的清除。方法。这项研究分为两部分。在A部分中，记录HD患者UP的患病率和强度，并每周检测3次基础血清IL-31水平。在A部分检测到血清IL-31水平的患者被纳入b部分，每个患者进行两次4小时的测试：常规HD或HD加HP （HDHP）。比较HD组和HDHP组IL-31的降低率（RR）。结果。40名患者完成了A部分，其中40%患有UP。UP患者血清IL-31的检出率明显高于非UP患者（50% vs 4.2%）。UP患者血清IL-31水平显著高于非UP患者（中位数：8.35pg/ml vs 7.8pg/ml）。血清IL-31水平与UP患者瘙痒强度显著相关（r = 0.55, P < 0.05）。8例患者入组并完成b部分。HD和HP联合治疗IL-31的RR优于HD单独治疗（34.26±1.43% vs 15.28±2.11%,P < 0.01）。结论：IL-31可能在尿毒症瘙痒的病理生理中起重要作用。在常规血液透析的基础上增加血液灌流可增强IL-31的清除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.