Alterations in degree centrality and functional connectivity associated with cognitive Impairment in myotonic dystrophy type 1:A Preliminary functional MRI study

IF 2.9 3区医学 Q2 NEUROSCIENCES

Neuroscience Pub Date : 2025-03-04 DOI:10.1016/j.neuroscience.2025.02.040

Sun Qian , He Di , Huang Pei , Hao Zeqi , Zhang Jiaxi , Liu Jun , Jia Xize , Xue Xiaomeng , Zhou Haiyan

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引用次数: 0

Abstract

Objectives

The study aimed to examine alterations in voxel-based degree centrality (DC) and functional connectivity (FC), and their relationship with cognitive impairments in patients with myotonic dystrophy type 1 (DM1).

Methods

Eighteen DM1 patients and eighteen healthy controls participated in the study and were assessed using a comprehensive neuropsychological battery. Voxel-wise DC and FC analyses were used to assess abnormalities in functional connections among aberrant hubs. Correlational analyses were used to identify and explore the relationship between DC and FC values and cognitive performance in DM1 patients.

Results

DM1 patients exhibited reduced DC in the bilateral Rolandic operculum, left inferior frontal gyrus (triangular part), right angular gyrus, right median cingulate and paracingulate gyri, and right middle temporal gyrus. Conversely, increased DC was observed in the right fusiform gyrus, right hippocampus and left inferior temporal gyrus. FC analysis revealed that altered connectivity predominantly occurred among the right middle temporal gyrus, right angular gyrus and left inferior frontal gyrus (triangular part). DC value in left inferior temporal gyrus showed significant correlations with scores from the Digital Span Test-Forward (r = -0.556, p = 0.025), the Digital Span Test −Backward (r = -0.588, p = 0.017), the Auditory Verbal Learning Test (r = -0.586, p = 0.017) and the Rey-Osterrieth Complex Figure test (copying version) (r = 0.536, p = 0.032) in DM1 patients. No significant correlations were discovered between FC values and neurocognitive performances.

Conclusion

The study demonstrated that abnormalities in DC and FC may become potential neuroimaging biomarkers for cognitive decline in DM1 patients.

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1型强直性肌营养不良患者认知障碍相关的度中心性和功能连通性改变：一项初步的功能性MRI研究。

目的：该研究旨在研究基于体素的度中心性（DC）和功能连通性（FC）的改变，以及它们与1型肌强直营养不良（DM1）患者认知障碍的关系。方法：18名DM1患者和18名健康对照者参与研究，并使用综合神经心理学电池进行评估。体素DC和FC分析用于评估异常中枢之间功能连接的异常。相关分析用于识别和探讨DC和FC值与DM1患者认知表现之间的关系。结果：DM1患者双侧rolanddic盖、左侧额下回（三角形部分）、右侧角回、右侧扣带中回和副扣带回、右侧颞中回DC减少。相反，右侧梭状回、右侧海马和左侧颞下回DC增加。FC分析显示，连接改变主要发生在右侧颞中回、右侧角回和左侧额下回（三角形部分）之间。直流值在左颞下回显示显著的相关性分数从数字跨度Test-Forward (r = -0.556,p = 0.025),数字广度测验向后(r = -0.588,p = 0.017),听觉言语学习测试(r = -0.586,p = 0.017)和Rey-Osterrieth复杂图测试(复制版)(r = 0.536,p = 0.032)在DM1病人。未发现FC值与神经认知表现有显著相关性。结论：本研究表明DC和FC异常可能成为DM1患者认知能力下降的潜在神经影像学生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience 医学-神经科学

CiteScore

6.20

自引率

0.00%

发文量

394

审稿时长

52 days

期刊介绍： Neuroscience publishes papers describing the results of original research on any aspect of the scientific study of the nervous system. Any paper, however short, will be considered for publication provided that it reports significant, new and carefully confirmed findings with full experimental details.