Triangesinenolides A–C: Trimeric Phthalides with Anti-Renal Fibrosis Potential from Angelica sinensis

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-26 DOI:10.1021/acs.orglett.5c0031710.1021/acs.orglett.5c00317

Hang Lv, Yu Mu, Bixuan Cao, Ping Yi, Nuerbiye Aobulikasimu, Zhongyuan Liu*, Xueshi Huang* and Li Han*,

引用次数: 0

Abstract

Trimeric phthalides in nature are rarely reported. This research successfully isolated three novel trimeric phthalides, triangesinenolides A–C (1–3), from Angelica sinensis. These compounds, derived from Z-ligustilide via diverse linkage patterns, display intricate polycyclic skeletons. Their structures were confirmed by spectroscopic and crystallographic analyses. Unlike previously identified trimeric phthalides, triangesinenolide C (3) is the first trimeric phthalide synthesized via [2 + 2]/[4 + 2] cycloaddition. In vitro assays evaluated the anti-renal fibrosis activity of trimeric phthalides for the first time.

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当归三聚体邻苯二甲酸酯A-C具有抗肾纤维化作用

自然界中的三聚体邻苯二甲酸酯很少有报道。本研究成功从当归中分离到3个新的三聚苯酞，triangesinenolides A-C（1-3）。这些化合物由z - liguslide通过不同的连锁模式衍生而来，显示出复杂的多环骨架。它们的结构通过光谱和晶体学分析得到了证实。与先前发现的三聚苯酞不同，三角烯内酯C(3)是第一个通过[2 + 2]/[4 + 2]环加成合成的三聚苯酞。体外实验首次评价了三聚苯酞的抗肾纤维化活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.