New NHC–Pd complexes bearing bulky steric hindrance: Synthesis and catalytic activity in the Heteroaryl–Heteroaryl Buchwald–Hartwig amination reaction

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-01 DOI:10.1016/j.tet.2025.134567

Xian-Fei Deng, Yan-Jun Chen, Li-Yu Yi, Ju Huang

引用次数: 0

Abstract

New bulky N-heterocyclic carbene (NHC) palladium complexes {[Pd-PEPPSI-IPr^tBuDBB]} were synthesized and characterized. The catalytic activity of the palladium complexes was evaluated via the direct C–N arylation of N-heteroaryl amines with aryl chlorides in aerobic conditions at 100 °C. Under the optimal conditions, 2 mol% of the bulky palladium was found to be very efficient and produced the desired cross-coupling products in high yields.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.