Preparation and characteristics of double-layer hydrogel-nanofiber FSG-(MgONRs/PCL/PVP) antibacterial membranes by electrospinning technology

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2025-03-01 DOI:10.1016/j.molstruc.2025.141903

Fuming Wang , Botian Zhu , Xuyang Feng , Hualin Zhang , Haoyou Jiang , Yaping Huang , Yongfang Qian , Xiaodong Xia , Ying Wang

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Abstract

In order to effectively promote wound healing, endowing wound dressings with antibacterial function is a future challenge in this field. Nanometer magnesium oxide antibacterial agents are suitable for loading on wound dressing substrates because of its safety, large specific surface area and non-drug resistance. In this study, the double-layer hydrogel-nanofiber FSG-(MgONRs/PCL/PVP) antibacterial membranes used for wound dressing were prepared using PCL/PVP (CV) as nanofiber substrates, fish skin gelatin (FSG) as scaffolds and MgO nanorods (MgONRs) with positive charge as antibacterial agents by electrospinning technology. Characterizations such as scanning electron microscopy (SEM), transmission electron microscope (TEM), attenuated total reflection fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and energy dispersive X-ray spectrometer (EDS) indicated that MgONRs were physically and evenly loaded on the membranes, and the NRCV-2.5 with positive charge were smooth and homogeneous with an average diameter of 339.6 ± 135.7 nm. In addition, antibacterial and water absorption tests indicate that antibacterial rate of the NSCV-2.5 against Escherichia coli (E. coli) is 100 %, and the water absorption rate of the NSCV-2.5 reaches 413 g/g, which has great development potential in the field of wound dressing with antibacterial property and water absorption.

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.