Pro-Aging Metabolic Reprogramming: A Unified Theory of Aging

IF 10.1 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering Pub Date : 2025-01-01 DOI:10.1016/j.eng.2024.09.010

Zhiguo Wang , Baofeng Yang

引用次数: 0

Abstract

Despite recent advances in understanding the biology of aging, the field remains fragmented due to the lack of a central organizing hypothesis. Although there are ongoing debates on whether the aging process is programmed or stochastic, it is now evident that neither perspective alone can fully explain the complexity of aging. Here, we propose the pro-aging metabolic reprogramming (PAMRP) theory, which integrates and unifies the genetic-program and stochastic hypotheses. This theory posits that aging is driven by degenerative metabolic reprogramming (MRP) over time, requiring the emergence of pro-aging substrates and triggers (PASs and PATs) to predispose cells to cellular and genetic reprogramming (CRP and GRP).

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来源期刊

Engineering Environmental Science-Environmental Engineering

自引率

1.60%

发文量

335

审稿时长

35 days

期刊介绍： Engineering, an international open-access journal initiated by the Chinese Academy of Engineering (CAE) in 2015, serves as a distinguished platform for disseminating cutting-edge advancements in engineering R&D, sharing major research outputs, and highlighting key achievements worldwide. The journal's objectives encompass reporting progress in engineering science, fostering discussions on hot topics, addressing areas of interest, challenges, and prospects in engineering development, while considering human and environmental well-being and ethics in engineering. It aims to inspire breakthroughs and innovations with profound economic and social significance, propelling them to advanced international standards and transforming them into a new productive force. Ultimately, this endeavor seeks to bring about positive changes globally, benefit humanity, and shape a new future.