Nanourchin-like Uricase-Poly(L-proline) Conjugate with Retained Enzymatic Activity, Mitigated Immunogenicity, and Sustained Efficacy Upon Repeated Administrations

IF 16.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-03-05 DOI:10.1002/anie.202425559

Ruichi Zhao, Yangming Zhang, Banlai Ruan, Hairuo Zhang, Niannian Lv, Jiayi Li, Yuhe R. Yang, Xiaozhou Luo, Hua Lu

引用次数: 0

Abstract

Poly(_L-proline) conjugated uricase was facilely produced via a grafting-from approach, which showed mitigated immunogenicity and preserved activity in vivo after repeated injections.

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纳米尿素样尿酸酶-聚(L-脯氨酸)共轭物可保持酶活性、降低免疫原性并在重复给药后保持药效

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.