Pea Peptides and Heavy Metal Neurotoxicity: Exploring Mechanisms and Mitigation Strategies in PC12 Cells.

IF 3.1 2区农林科学 Q2 CHEMISTRY, APPLIED

Plant Foods for Human Nutrition Pub Date : 2025-03-04 DOI:10.1007/s11130-025-01322-x

Ning Li, Ningning Cui, Tiange Li, Peijun Zhao, Ibrahim A Bakry, Qian Li, Yongxia Cheng, Gianni Galaverna, Huijie Yang, Fangyu Wang

引用次数: 0

Abstract

Calsyntenin-1 (Clst1) is a sensitive indicator of lead (Pb) toxicity in neural tissue. This study was designed to investigate the impact of lead exposure on Clst1 expression in PC12 cells and the mitigating effect of pea peptide 4 (PP4) on lead-induced neurotoxicity. Data showed that lead exposure, at varying doses and durations, disrupted the mRNA expression and protein levels of Clstn1 in PC12 cells. However, immunofluorescence results showed that treatment with PP4 significantly increased Clstn1 protein expression in the Pb + PP4 and PP4 groups compared to the Pb groups (P < 0.05). Lead exposure activates the JNK and p38 pathways; at the same time, PP4 treatment enhances ERK pathway activation and reduces JNK and p38 activation.

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钙调蛋白-1（Calsyntenin-1，Clst1）是神经组织中铅（Pb）毒性的敏感指标。本研究旨在探讨铅暴露对 PC12 细胞中 Clst1 表达的影响，以及豌豆肽 4（PP4）对铅诱导的神经毒性的缓解作用。数据显示，不同剂量和持续时间的铅暴露会破坏 PC12 细胞中 Clstn1 的 mRNA 表达和蛋白水平。然而，免疫荧光结果显示，与铅组相比，Pb + PP4 组和 PP4 组的 Clstn1 蛋白表达明显增加（P

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plant Foods for Human Nutrition 工程技术-食品科技

CiteScore

6.80

自引率

7.50%

发文量

审稿时长

12-24 weeks

期刊介绍： Plant Foods for Human Nutrition (previously Qualitas Plantarum) is an international journal that publishes reports of original research and critical reviews concerned with the improvement and evaluation of the nutritional quality of plant foods for humans, as they are influenced by: - Biotechnology (all fields, including molecular biology and genetic engineering) - Food science and technology - Functional, nutraceutical or pharma foods - Other nutrients and non-nutrients inherent in plant foods