Enzymatically Ligated Nucleic Acid Nanocapsules for the Delivery of Therapeutic Nucleic Acids and Small Molecule Drugs.

Q4 Biochemistry, Genetics and Molecular Biology

Methods in molecular biology Pub Date : 2025-01-01 DOI:10.1007/978-1-0716-4402-7_4

Jenna N Cannata, Jessica L Rouge

引用次数: 0

Abstract

Spherical nucleic acids (SNAs) offer intriguing properties for cellular uptake and stability. A novel SNA-like structure known as the nucleic acid nanocapsule (NAN) combines the benefits of SNAs with the added properties of nucleic acid functionalization and drug cargo release. Herein, we will discuss various ways NANs can be adapted to allow for gene targeting via the delivery of nucleic acids, as well as the delivery of small molecule drugs for combination therapies.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Methods in molecular biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.00

自引率

0.00%

发文量

3536

期刊介绍： For over 20 years, biological scientists have come to rely on the research protocols and methodologies in the critically acclaimed Methods in Molecular Biology series. The series was the first to introduce the step-by-step protocols approach that has become the standard in all biomedical protocol publishing. Each protocol is provided in readily-reproducible step-by-step fashion, opening with an introductory overview, a list of the materials and reagents needed to complete the experiment, and followed by a detailed procedure that is supported with a helpful notes section offering tips and tricks of the trade as well as troubleshooting advice.