Cancer-associated fibroblasts in breast cancer in the single-cell era: Opportunities and challenges

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-02-28 DOI:10.1016/j.bbcan.2025.189291

Jingtong Yang, Benkai Xin, Xiaoyu Wang, Youzhong Wan

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引用次数: 0

Abstract

Breast cancer is a leading cause of morbidity and mortality in women, and its progression is closely linked to the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), key components of the TME, play a crucial role in promoting tumor growth by driving cancer cell proliferation, invasion, extracellular matrix (ECM) remodeling, inflammation, chemoresistance, and immunosuppression. CAFs exhibit considerable heterogeneity and are classified into subgroups based on different combinations of biomarkers. Single-cell RNA sequencing (scRNA-seq) enables high-throughput and high-resolution analysis of individual cells. Relying on this technology, it is possible to cluster complex CAFs according to different biomarkers to analyze the specific phenotypes and functions of different subpopulations. This review explores CAF clusters in breast cancer and their associated biomarkers, highlighting their roles in disease progression and potential for targeted therapies.

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乳腺癌是女性发病和死亡的主要原因，其进展与肿瘤微环境（TME）密切相关。癌症相关成纤维细胞（CAFs）是肿瘤微环境的关键组成部分，通过驱动癌细胞增殖、侵袭、细胞外基质（ECM）重塑、炎症、化疗抵抗和免疫抑制，在促进肿瘤生长方面发挥着至关重要的作用。CAFs 表现出相当大的异质性，并根据不同的生物标志物组合被分为不同的亚组。单细胞 RNA 测序（scRNA-seq）可对单个细胞进行高通量、高分辨率的分析。依靠这项技术，可以根据不同的生物标志物对复杂的CAFs进行聚类，从而分析不同亚群的特定表型和功能。这篇综述探讨了乳腺癌中的CAF集群及其相关生物标志物，强调了它们在疾病进展中的作用和靶向治疗的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.