Antigen-specific immunotherapy of multiple sclerosis and other autoimmune diseases

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-02-22 DOI:10.1016/j.semarthrit.2025.152682

David C. Wraith

引用次数: 0

Abstract

Current therapies for autoimmune diseases do not address the underlying cause of disease, the failure of immune tolerance to self. The non-specific therapies currently used to treat autoimmune diseases increase the risk of infections and cancers. Antigen-specific therapies target pathogenic autoreactive lymphocytes while preserving protective immune responses. This short synthesis will review our laboratory's work on the design and development of antigen-specific immunotherapies for multiple sclerosis and other autoimmune diseases.

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抗原特异性免疫治疗多发性硬化症和其他自身免疫性疾病。

目前对自身免疫性疾病的治疗并没有解决疾病的根本原因，即免疫耐受的失败。目前用于治疗自身免疫性疾病的非特异性疗法增加了感染和癌症的风险。抗原特异性疗法针对致病性自身反应性淋巴细胞，同时保留保护性免疫反应。这篇简短的综述将回顾我们实验室在设计和开发针对多发性硬化症和其他自身免疫性疾病的抗原特异性免疫疗法方面的工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.