The Molecular Mechanisms and Treatment of Cancer-Related Cachexia.

IF 0.7 4区医学 Q4 NUTRITION & DIETETICS

Journal of nutritional science and vitaminology Pub Date : 2025-01-01 DOI:10.3177/jnsv.71.1

Yongfei You, Yong Wang, Guohua Zhang, Yong Li

引用次数: 0

Abstract

Cancer cachexia is a multifactorial syndrome characterized by persistent skeletal muscle loss, with or without fat loss, which cannot be completely reversed by traditional nutritional support and leads to impaired organ function. Cachexia seriously reduces the quality of life of (QOL) patients, affects the therapeutic effect against cancers, increases the incidence of complications, and is an important cause of death for patients with advanced cancers. To date, no effective medical intervention has completely reversed cachexia, and no medication has been agreed upon. Here, we describe recent advances in the diagnosis, molecular mechanism and treatment of cancer-related cachexia.

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癌症相关恶病质的分子机制及治疗。

癌症恶病质是一种多因素综合征，其特征是骨骼肌持续减少，伴有或不伴有脂肪减少，这种情况不能通过传统的营养支持完全逆转，并导致器官功能受损。恶病质严重降低患者生活质量（QOL），影响肿瘤治疗效果，增加并发症发生率，是晚期癌症患者死亡的重要原因。迄今为止，没有任何有效的医疗干预能够完全逆转恶病质，也没有达成一致的药物。本文就癌症相关恶病质的诊断、分子机制和治疗等方面的最新进展作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of nutritional science and vitaminology 医学-营养学

CiteScore

1.80

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Nutritional Science and Vitaminology is an international medium publishing in English of original work in all branches of nutritional science, food science and vitaminology from any country. Manuscripts submitted for publication should be as concise as possible and must be based on the results of original research or of original interpretation of existing knowledge not previously published. Although data may have been reported, in part, in preliminary or abstract form, a full report of such research is unacceptable if it has been or will be submitted for consideration by another journal.